

CRYOTHERAPY + ULTRASOUND THERAPY
Cryoultrasound
The CrioSix Cryoultrasound combines the proven benefits of cryotherapy and ultrasound therapy into one powerful medical device. Widely trusted by athletes and clinicians, this innovative solution effectively targets muscle injuries and penetrates deep into connective tissue layers to accelerate healing and recovery. With its clinically proven technology, CrioSix Cryoultrasound therapy device is a game changer for pain relief and injury recovery.
230 V, 50 Hz
1 MHz ultrasound source – Quartz foil
Maximum effective intensity – 3 Watt x cm2
Continuous – Pulsed – Intermittent
Square wave
50 HZ
3 Sec action and 2 Sec pause
7 cm2 / 4.9 cm2
Maximum effective intensity – 2.5 Watt x cm2
Up to -8 ° C
48 × 36 x 117h cm
Approximately 75 kg
Applied standards The design of the medical device took place using the applicable technical standards.

WHAT IS COLD ULTRASOUND?
Cryotherapy = pain relief and inflammatory reduction
Ultrasound = enhanced injury recovery through growth factor promotion
The speedy recovery that cryoultrasound therapy provides for athletes was the primary factor that contributed to its early success in the sporting world. Cyro-US therapy has since made its way into traditional methods of treatment (Vulpiani et al., 2015).
WHAT IS CRYO-ULTRASOUND THERAPY?
Cryo-US therapy seamlessly combines the benefits of cryotherapy and therapeutic ultrasound, making it an advanced solution for reducing edema, pain, and promoting recovery. A cornerstone of modern injury treatments, cryotherapy effectively manages swelling and provides pain relief. The ultrasound component delivers high-frequency oscillatory sound waves with a peak pressure of just 0.5 bar, ensuring a gentler approach compared to shock wave therapy.
This dual-action therapy enhances healing by:
- Increasing blood flow and relaxing muscles through internal heat.
- Improving collagen flexibility and triggering a pro-inflammatory response for faster recovery.
- Leveraging non-thermal effects like cavitation and microstreaming to stimulate fibroblast activity, protein synthesis, tissue regeneration, blood flow, and even bone healing.
Cryo-US therapy is trusted by clinicians, physiotherapists, and sports therapists for its ability to target deep tissue layers and optimize recovery outcomes.

HOW DOES CRYO-ULTRASOUND THERAPY WORK?
This therapy combines cold and ultrasound treatments to reduce pain, inflammation, and edema. Cold therapy suppresses pain receptors and restricts blood flow, controlling edema and providing pain relief. Ultrasound generates high-frequency sound vibrations that produce mechanical, thermal, chemical, and cavitation effects, aiding in tissue healing and reducing inflammation. Ultrasound also improves vascularization and removes inflammatory molecules. The combination of these therapies provides deep micromassage and a calming effect on damaged tissues (Paoloni et al., 2015).

ADVANTAGES OF CRYO-ULTRASOUND THERAPY?
- MUSCLE RECOVERY
- IMPROVED SLEEPING
- CHRONIC PAIN RELIEF
Cryotherapy is commonly used to accelerate the healing of muscles and tissues after physical activity or injury. This is based on the physiological changes that occur in the body in response to exposure to cold and hot temperatures.
When your body encounters cooler temperatures, it initiates vasoconstriction, narrowing blood vessels and directing blood toward your organs. This process concentrates oxygen and nutrients in the blood. As the body warms up, vasodilation occurs, widening the blood vessels and returning oxygen-rich blood to the tissues, which helps flush out inflammation and toxins, aiding in recovery.
Cryo-US therapy alleviates chronic pain by slowing nerve impulse transmission, a known effect of cold temperatures. Cryotherapy has also been shown to improve sleep quality by reducing muscle inflammation and damage, and it activates the sympathetic nervous system, which plays a role in the sleep process.
Cryo in action

CrioSix is used by a large number of sporting teams and premium clinics around the world.
“Instant relief for the patient great for rebookings”
September 2023
CRYO-ULTRASOUND THERAPY CLINICAL STUDIES?
1. Vulpiani et al. (2015) and Vural et al. (2014) found that cryo-ultrasound therapy effectively combines therapeutic ultrasound and cryotherapy, improving recovery and pain relief. Cryotherapy reduces the thermal impact of ultrasound, allowing patients to benefit from both treatments’ mechanical and biological effects. This combination enhances the overall effectiveness of the therapy, as the reduction in deep tissue temperature increases the density of ultrasound waves.

2. Costantino et al. (2014) found that cryo-ultrasound therapy is effective for treating persistent plantar fasciitis, providing long-lasting pain relief and improved function. The combination of cryotherapy and ultrasound enhances tissue healing and reduces inflammation, making it a valuable option for chronic conditions.
3. Liu et al. (2019), evaluated cryo-ultrasound therapy for its effectiveness in treating chronic shoulder tendinopathy. The study found that patients receiving cryo-ultrasound therapy showed significant improvement in pain reduction and functional outcomes compared to those receiving standard treatments.